ChIP-seq data analysis
Contributors
Authors:
Leily Rabbani
Bérénice Batut
Questions
What is ChIP-seq?
Objectives
Identify ChIP-seq data
last_modification Last modification: Jul 26, 2021
ChIP-seq
- Chromatin ImmunoPrecipitation combined with sequencing
- Identifying the location of proteins binding sites
- Transcription Factors
- Histone modifications
- 2 Types of sequenced data
- ChIP data
- Input data
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Generating ChIP-seq data
Source: Wikipedia
ChIP vs Input
Studying the effect of SCHMD1 protein in chromosome X
SCHMD1 in known to have an effect on gene expression in X chromosome
Chen-Yu Wang et al. 2018; Vivek Bhardwaj, Steffen Heyne et al. 2018
Speaker Notes We probe a potential architectural role for SMCHD1 and investigate the mechanism by which it shapes the Xi and represses gene expression